課程資訊
課程名稱
 結構生物學概論
Introduction to Structural Biology 
開課學期
 109-1 
授課對象
 生命科學院  生化科技學系  
授課教師
 楊啟伸 
課號
 BST5008 
課程識別碼
 B22EU0180 
班次
  
學分
 2.0 
全/半年
 半年 
必/選修
 選修 
上課時間
 星期四6,7(13:20~15:10) 
上課地點
 農化二B10 
備註
 本課程以英語授課。先修科目：生物化學上（或第一學期）或生物化學概論。
總人數上限：80人 
Ceiba 課程網頁
 http://ceiba.ntu.edu.tw/1091BST5008_ 
課程簡介影片
 
核心能力關聯
 本課程尚未建立核心能力關連
課程大綱
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課程概述

This is a class integrates the concepts of structural biology and bioinformatics. There are four major parts: 1) The basic principles of how 20 amino acids affect protein structures. 2) The modern methods currently adopted to resolve atomic resolution of protein structures will be explained. 3) Software tools for protein structure display and analysis, including PyMol, Swiss PDB viewer and UCSF Chimera, will be demonstrated. Several bioinformatics concepts and web servers will be mentioned in this class. 4) The mechanism behind protein structure and functional exertion will be emphasized and exercised via student presentations. 

課程目標
 1. Understand amino acids and protein structures.
2. Modern approaches to resolve protein structure.
3. Protein structure and function.
4. Software-based analysis of protein sequence.
5. Bioinformatic theories
6. Current developments of protein structural-related bioinformatics methods. 
課程要求
 This class will be taught in English. 
預期每週課後學習時數
  
Office Hours
 另約時間 備註： This class mainly does Q&A thorugh e-mail. 
指定閱讀
 Newly published journal articles. 
參考書目
 1. David Whitford (2005). Proteins : Structure and Function. John Wiley & Sons, Hoboken, NJ. USA.
2. Gregory A. Petsko and Dagmar Ringe (2003). Protein Structure and Function, 4th ed., New Science Press, Waltham, MA.
3. Materials are updated according to new journal publications. 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 Final Exam 
30% 
 Written Exam, Take-home/Open-book style 
2. 
 Personal Report 
20% 
 Protein structural analysis with software tools taught in this class 
3. 
 Presentation 
20% 
 Presentation of an assigned topic in Engilsh 
4. 
 Mid-term 
30% 
 Written Exam 
 
課程進度
週次
日期
單元主題
第1週
 9/17  1. Concepts of structural biology
2. What will be taught in this class 
第2週
 9/24  Software tools
Amino Acids (1/2) 
第3週
 10/01  【Happy Moon Festival】No class
 
第4週
 10/08  Amino Acids (2/2) 
第5週
 10/15  Amino Acids as Basic Elements In Protein Structure：
1. Amino Acids as Basic Elements In Protein Structure

2. Five different basic structural elements: Alpha helix, Beta sheet, Beta turn, Beta bulge and Beta-Alpha-Beta 
第6週
 10/22  1. Five major arrangements of protein structure
2. Protein classification 
第7週
 10/29  Protein function inside a cell
Protein functional domain
Protein conformational changes 
第8週
 11/05  Let's talk about structural resolving methods, generally.
1. X-ray diffraction
2. NMR & CyroEM
3. Considerations of Protein Structural Resolving: Which Method to Use? 
第9週
 11/12  Mid-term Exam 
第10週
 11/19  *******************************************
*** Pick the topic for your Presentation ***
*******************************************
X-ray diffraction method to resolve atomic structure 
第11週
 11/26  Structural Biology & Bioinformatics
Prediction of 2nd Structure With Pen-and-paper (unplug style)
PDB file is actually a text file 
第12週
 12/03  Insights of Various Protein Structures 
第13週
 12/10  Extra Class 
第14週
 12/17  Life Science and Structural in real world 
第15週
 12/24  Presentation preparation break 
第16週
 12/31  Group presentation 1 and 2 
第17週
 1/07  Group presentation 3, 4 and 5